KEGG   REACTION: R06483
Entry
R06483                      Reaction                               
Definition
2-Methylpropanoyl-CoA + 5 Methylmalonyl-CoA + 7 Malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1b'' aglycone + 12 CO2 + 13 CoA + 6 H2O + 9 NADP+
Equation
C00630 + 5 C02557 + 7 C00083 + 9 C00005 + 9 C00080 <=> C11961 + 12 C00011 + 13 C00010 + 6 C00001 + 9 C00006
Comment
type I polyketide synthase, AveA1-4
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C00630  C00010_C02557
RC02913  C00630_C11961
RC02915  C02557_C11961
RC02920  C02557_C11961
RC02921  C02557_C11961
RC02922  C02557_C11961
RC02924  C00083_C11961
RC02925  C00083_C11961
RC02926  C00083_C11961
RC02927  C00083_C11961
RC02928  C00083_C11961
RC02929  C00083_C11961
RC02930  C00083_C11961
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Orthology
K14371  avermectin polyketide synthase AveA1
K24567  avermectin polyketide synthase AveA2
K24568  avermectin polyketide synthase AveA3
K24569  avermectin polyketide synthase AveA4

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (14)   
   KEGG RCLASS (14)   
Gene (8)   
   KEGG ORTHOLOGY (4)   
   KEGG GENES (4)   
All databases (39)   

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